TrehaShield™ is a cutting-edge dietary material formulated to fortify your immune system and enhance overall wellness. It features a synergistic blend of Trehalose Alcohol, Reishi Mushroom Extract, American Ginseng Extract, and Red Wine Polyphenols. This unique formula combines modern nutritional science with premium natural ingredients sourced from Canada, delivering comprehensive immune support along with additional antioxidant and metabolic benefits. Below, we explore the metabolic pathways and scientific mechanisms of each ingredient – with a focus on Trehalose Alcohol – and how they work together to keep you healthy and resilient.
Trehalose Alcohol: Metabolic Pathways & Immune Mechanisms
Trehalose Alcohol is a natural disaccharide (comprised of two glucose molecules) that serves as the cornerstone of TrehaShield’s formula. Trehalose is metabolized in the human body by a specific enzyme called trehalase, which splits trehalose into two glucose units for absorption.[i]
Trehalase is found mainly in the intestinal brush border, allowing trehalose to be digested at a controlled rate. As a result, trehalose provides a steady, slow-burning source of energy without spiking blood sugar levels. In fact, studies show that ingesting trehalose does not evoke the rapid blood glucose surge seen with regular sugar and causes a lower insulin response. [ii]
This gentler effect on blood sugar is coupled with a higher activation of GLP-1 (an incretin hormone), and markedly lower GIP (a gut peptide linked to fat storage), indicating a healthier metabolic response compared to glucoseii . By avoiding abrupt glucose and insulin spikes, trehalose helps maintain balanced energy metabolism and may support metabolic health (as evidenced by improved glucose tolerance in human studies)ii.
Beyond its role as a functional carbohydrate, trehalose has gained attention for its remarkable cellular effects. Scientific research has identified trehalose as a potent inducer of autophagy – the cell’s internal “cleanup” process – triggering it through pathways independent of mTOR (the usual nutrient-sensing regulator)[iii]
. Autophagy is a fundamental mechanism where cells remove dysfunctional components, pathogens, and debris, thereby rejuvenating themselves. By activating autophagy, trehalose helps cells to clear out toxins and even infectious agents, which is directly relevant to immune defense. In fact, autophagy induction is known to be critical for both innate and adaptive immunity, helping the body control intracellular infections and supporting proper immune responsesiii. Trehalose’s ability to stimulate autophagy has been demonstrated in multiple contexts – it can even restore autophagic flux in immune cells when certain viruses (like HIV) have impaired this processiii. By reviving the cell’s own defenses, trehalose empowers the immune system to recognize and eliminate threats more effectively. Notably, a recent mini-review highlighted that trehalose is “known to impair viral function through the autophagy system”iii, suggesting a protective effect against viral infections via enhanced cellular housekeeping.
Trehalose also acts as a molecular shield for cells under stress. In nature, this sugar allows organisms like plants and fungi to survive extreme conditions (drought, freezing, etc.) by stabilizing proteins and membranes. When humans consume trehalose, it confers some of these protective benefits at the cellular level: it functions as an osmoprotectant and antioxidant, guarding cells (including immune cells) from oxidative and environmental stress. Researchers have described trehalose’s effects as inducing a “fasting-like” metabolic state in tissues, activating processes similar to those seen during caloric restriction or exercise (such as AMPK activation and increased autophagic flux)i. These processes can translate into broad health benefits. For example, trehalose supplementation in research settings has reduced cardiometabolic risk factors (improving insulin sensitivity, lowering fat accumulation in the liver, etc.)i, and even shown neuroprotective tendencies by clearing protein aggregates in brain modelsi. In summary, Trehalose Alcohol is a powerhouse ingredient that not only provides gentle energy and metabolic balance, but also boosts cellular renewal mechanisms and immune function. By including high-grade trehalose in each serving, TrehaShield™ gives your body the tools to maintain strong defenses at the most fundamental level – within your cells.
Reishi Mushroom Extract: Ancient Immune Tonic with Canadian Quality
Reishi (Ganoderma lucidum), known as Lingzhi in Chinese, is a legendary medicinal mushroom prized for over 2,000 years for promoting vitality and longevity. TrehaShield™ harnesses a concentrated dose of Reishi extract, derived from carefully cultivated Canadian-grown Reishi mushrooms to ensure purity and potency. This “mushroom of immortality” is rich in bioactive compounds such as β-glucan polysaccharides and triterpenes, which modern science has shown to have profound immune-modulating effects[iv].
Immune system enhancement is Reishi’s most renowned benefit. Reishi polysaccharides (particularly β-1,3/1,6-glucans) act as biological response modifiers: they bind to receptors on immune cells (like macrophages, dendritic cells, and natural killer cells), essentially “training” the immune system to respond more robustly to infections or abnormal cells. Clinical research supports these immune benefits. For instance, in a controlled study of cancer patients, those given Reishi extract showed significant enhancements in immune parameters, including higher counts of total T-cells and natural killer (NK) cells, along with an improved CD4/CD8 T-cell ratioiv. These changes corresponded with improved well-being, confirming Reishi’s role as an immunomodulator in humans. It’s no surprise that many Ganoderma lucidum products on the market are promoted as immune-boosting supplements, as agents that enhance the host immune function are expected to improve the body’s resistance to illnessesiv. In TrehaShield™, Reishi works as a force-multiplier for your immune system – helping to activate white blood cells, increase the production of protective immune molecules, and maintain immune surveillance against pathogens and even abnormal cells (as suggested by its use in complementary cancer care).
Reishi is also a potent antioxidant and cellular protector. Its array of triterpenoids and polysaccharides help combat oxidative stress and inflammation that can otherwise weaken immune defenses. Scientific reports show that components of Reishi protect immune cells from oxidative damage, allowing them to maintain their vigilance and functioniv
. In fact, small human studies have observed that Reishi supplementation can increase plasma antioxidant capacity, effectively raising the body’s ability to neutralize free radicals. This antioxidant effect not only shields immune cells but also supports cardiovascular and liver health (historically, Reishi has been used for liver detox and has shown hepatoprotective effects in studies4). Reishi’s triterpenes further exhibit anti-inflammatory properties, helping to regulate an overactive immune response and maintain balance.
By sourcing Reishi extract from Canadian cultivation, TrehaShield™ ensures a high-quality ingredient with a rich profile of active compounds. The cold, clean environment and stringent farming practices yield Reishi mushrooms of exceptional purity and strength. With scientific backing confirming Reishi’s ability to boost immune response and antioxidant status, this extract plays a crucial role in TrehaShield’s mission to fortify your health. It brings together the best of ancient herbal wisdom and modern clinical evidence, truly earning its title as a “super mushroom” for the immune system.
American Ginseng Extract: Adaptogenic Immune Booster from Canada
TrehaShield™ includes pure American Ginseng extract, derived from Panax quinquefolius roots grown in North America (particularly Canada). American ginseng – often called “Canada ginseng” when referring to crops from Ontario/British Columbia – is a celebrated adaptogen with a centuries-long history of use for enhancing energy, reducing stress, and bolstering the body’s defenses. The extract in TrehaShield is rich in ginsenosides, the active saponins that give ginseng its medicinal power, and is standardized for consistent efficacy.
Immune support is one of the most well-documented benefits of American ginseng. Notably, this herb has been the subject of clinical trials in Canada examining its ability to prevent colds and flu. The results are impressive: in a large randomized placebo-controlled trial, healthy adults who took North American ginseng extract over 4 months experienced significantly fewer colds on average, a lower risk of recurring colds, and shorter duration of symptoms compared to those on placebo[v] .
In practical terms, ginseng reduced the incidence of colds and also made any breakthrough illnesses milder and quicker to resolve – clear evidence of a strengthened immune resilience. Another study focusing on older adults (a population with generally weaker immune response) found that an Ontario-grown ginseng extract (CVT-E002) led to an 89% reduction in the risk of developing cold or flu over an 8-12 week period, versus placebo[vi]. Most participants had received flu vaccinations, yet the ginseng still provided substantial additional protection, highlighting its value as an immune supplement. In summary, regular intake of American ginseng has been shown to enhance the body’s resistance to upper respiratory infections in diverse groups.
From a mechanistic perspective, American ginseng appears to “activate” the immune system on multiple levels. Laboratory research and animal studies indicate that ginseng components can increase the activity of various immune cells. For example, experiments have shown ginseng extracts stimulate the production of tumor necrosis factor-alpha (TNF-α) by lung macrophages, a cytokine that helps orchestrate immune responses[vii],[viii]. One of ginseng’s key compounds, Rg1 ginsenoside, has been associated with improvements in both humoral and cell-mediated immunity – it increased populations of T-helper cells, T-lymphocytes, and NK cells in research models[ix],[x],[xi]. These effects suggest ginseng can prime the immune system to respond more vigorously to infections and even to cancerous changes. Indeed, American ginseng is often cited as an herbal immunostimulant, and even authoritative sources note that it “can increase the activity of the immune system”. Importantly, ginseng achieves this modulation in a balancing manner – as an adaptogen, it helps normalize immune function (upregulating it when weak, while also calming excessive inflammation).
Beyond immunity, American ginseng provides additional health benefits that complement its role in TrehaShield™. It is well known for boosting energy and fighting fatigue – including clinical evidence for reducing cancer-related fatigue in patients[xii],[xiii],[xiv]– and for improving mental performance. In fact, ginseng has shown benefits for cognitive function and memory in research, likely due to its anti-inflammatory and antioxidant actions on brain cells[xv],[xvi],[xvii]. Speaking of antioxidants, American ginseng is rich in polyphenolic compounds and has demonstrated notable antioxidant properties in lab studies. By scavenging free radicals, ginseng helps protect tissues (such as the cardiovascular system) from oxidative stress and supports healthy aging. The herb has also been studied for metabolic effects: it may aid in blood sugar regulation (several trials found improved blood glucose control in type 2 diabetics using American ginseng), and it potentially protects against complications of metabolic stress by reducing oxidative damage.
With TrehaShield’s Canadian-sourced American Ginseng extract, you receive a well-rounded adaptogen that energizes the body and reinforces immune defenses. This ingredient’s scientifically backed immune-enhancing properties – from increasing immune cell counts to cutting down colds in clinical trials – make it an indispensable part of the TrehaShield™ formula, working in harmony with Reishi and Trehalose to keep you at your healthiest.
Red Wine Polyphenols: Antioxidant Powerhouse Supporting Immunity and Wellness
To round out its immune-boosting formula, TrehaShield™ provides Red Wine Polyphenols – a concentrated extract of the beneficial compounds found in red wine (such as resveratrol, proanthocyanidins, and other grape antioxidants). These polyphenols are included for their well-known effects on oxidative stress, cardiovascular health, and immune modulation. This dose provides a significant ORAC (antioxidant capacity) boost and works synergistically with the other ingredients.
Antioxidant protection is the hallmark of red wine polyphenols. Resveratrol, in particular, has been extensively studied for its ability to protect cells and organs from oxidative damage. It helps neutralize free radicals and has been linked to benefits like improved heart health and anti-aging effects. Antioxidants in red wine “may help protect the lining of blood vessels” and prevent oxidative cholesterol damage, which contributes to the famous “French Paradox” of heart health. Resveratrol has also been noted to support healthy blood flow by reducing inflammation and inhibiting unwanted blood clotting. In TrehaShield™, the red wine polyphenols serve to shield your immune cells and other tissues from oxidative stress, ensuring that the immune system can function optimally without being hampered by excess free radicals. By bolstering the body’s antioxidant network (in tandem with Reishi and Ginseng’s antioxidants), these polyphenols help reduce the overall inflammatory load and contribute to healthier aging and cardiovascular function.
Emerging research also highlights the immune-modulating effects of red wine polyphenols. Polyphenols don’t just passively scavenge free radicals; they actively interact with cell signaling pathways and gene expression. Scientific reviews have found that polyphenols can stimulate both innate and adaptive immune responses[xviii]. For instance, in ex vivo studies, red wine polyphenols increased the release of key cytokines like interleukin-12 (IL-12) and interferon-gamma (IFN-γ) from human immune cells18. These cytokines are crucial for directing immune reactions (IL-12 helps activate natural killer cells and prime T-cells, while IFN-γ is vital for anti-viral and anti-tumor immunity). Polyphenols have also been shown to enhance the production of immunoglobulins (antibodies) xviii, indicating a boost to adaptive immunity. Another striking finding is that red wine polyphenols stimulated human mononuclear immune cells to release **nitric oxide (NO)xviii. Nitric oxide is not only beneficial for blood vessel health, but also serves as a defense molecule against pathogens – immune cells use NO to kill bacteria and inhibit viruses. By promoting NO release (beyond what’s normally seen from just endothelial cells), polyphenols may improve the immune system’s ability to clear infectionsxviii. These findings underscore that polyphenols have a direct positive impact on immune responsiveness, making them a perfect complement to Reishi and Ginseng in this formula. Additionally, polyphenols can act as prebiotics in the gut, fostering healthy gut microbiota which in turn supports immune function – though this is an indirect benefit, it’s another way red wine compounds contribute to overall immunity and health.
In essence, the Red Wine Polyphenols in TrehaShield™ serve dual roles: they are powerful antioxidants that protect your cells, and immune allies that fine-tune immune signals and reduce harmful inflammation. This component brings a touch of the Mediterranean diet’s health benefits into our material, all without any alcohol. It reinforces the idea that a well-supported immune system isn’t just about fighting germs in the moment, but also about maintaining the long-term health of the body’s cells and organs.
Synergistic Effects for Comprehensive Health
While each ingredient in TrehaShield™ offers impressive benefits on its own, the true strength of this material lies in the synergy between its components. The formula was scientifically designed so that these ingredients work in concert, enhancing each other’s effects and covering multiple facets of health:
- Multi-Pathway Immune Support: Trehalose Alcohol, Reishi, Ginseng, and Polyphenols each boost immunity via different mechanisms. Trehalose activates internal cell defense (autophagy), Reishi and Ginseng directly stimulate immune cells and cytokines, and Polyphenols modulate immune signaling and gut health. Together, they provide a 360-degree enhancement of the immune system – from the innate barriers to adaptive responses. For example, Reishi’s beta-glucans might activate a macrophage, which is further kept in peak condition by trehalose’s autophagic cleanup and protected from oxidative stress by polyphenols. This comprehensive approach means your immune system is not only more responsive but also more resilient.
- Antioxidant and Cellular Protection: The antioxidant capacity of TrehaShield™ is amplified by combining mushroom antioxidants (e.g. Reishi’s triterpenes), ginsenoside and polyphenol antioxidants, and trehalose’s stress-protective effects. This network of antioxidants works synergistically to reduce oxidative damage in the body. By quenching free radicals, they protect immune cells, brain cells, and cardiovascular tissues from premature aging and dysfunction. You may experience this as better vitality, reduced inflammation, and improved recovery from stress. Notably, raising antioxidant levels (as Reishi has been shown to do in humansiv) also frees the immune system to focus on threats like microbes, rather than cleaning up oxidative messes.
- Energy, Metabolic and Stress Support: TrehaShield™’s ingredients also complement each other in maintaining healthy metabolism and energy levels. Trehalose provides steady energy without crashes, while American Ginseng fights fatigue and boosts mental alertness. Ginseng’s adaptogenic qualities, along with Reishi’s adaptogenic and calming effects, help your body handle stress more effectively, whether it’s physical stress or environmental. Trehalose’s activation of “fasting-like” pathways and ginseng’s support for blood sugar control together promote metabolic balance, which is crucial for sustained energy and a robust immune response (since metabolic health and immune health are closely linked). Many users report that such a combination leads to improved overall wellness, not just fewer sick days.
- Quality and Bioavailability: All ingredients in TrehaShield™ are chosen for their quality and sourced to maximize potency – Canadian Reishi and Ginseng are prized for their rich active compound content. Trehalose used is of high purity (with GRAS status for safetyiii), and the red wine polyphenols are extracted to retain a broad spectrum of beneficial compounds. The doses are balanced so they can be effectively utilized by the body. For example, trehalose is enough to trigger cellular effects without causing gastric upset, and it may even enhance the uptake or utilization of the herbal extracts by providing a mild energy substrate. The synergy extends to bioavailability: certain polyphenols can improve endothelial function and microcirculation, potentially aiding delivery of ginseng and Reishi’s active constituents to tissues. In short, each component makes the others more effective, resulting in a material that is greater than the sum of its parts.
Summary of Benefits
TrehaShield™ is a scientifically advanced immune-boosting material that brings together the best of nature and research. By incorporating Trehalose Alcohol, Reishi mushroom, American Ginseng, and Red Wine Polyphenols into your routine, you can expect a multitude of health benefits, all grounded in scientific findings:
- Robust Immune System Function: Strengthens both innate and adaptive immunity through multiple pathways. Trehalose-induced autophagy helps immune cells clear pathogens, Reishi and Ginseng extracts directly increase immune cell activity (enhancing T-cells, NK cells, and cytokine production), and Polyphenols further stimulate protective immune responses. Clinical trials confirm fewer infections and milder symptoms with these ingredientsv.
- Enhanced Cellular Protection & Autophagy: Promotes healthy cellular turnover and cleanup. Trehalose activates autophagy (independent of mTOR) to remove cellular waste and defend against viral invasion[xix]. This process, along with potent antioxidants from Reishi and Polyphenols, protects cells from oxidative stress and aging. Your cells function more efficiently, contributing to longevity and vitality.
- Powerful Antioxidant Defense: Provides a broad spectrum of antioxidants that neutralize free radicals and reduce inflammation. Reishi mushroom has demonstrated an increase in antioxidant capacity in humans, and red wine polyphenols like resveratrol are famed for cardiovascular and cellular protection. This antioxidant shield helps safeguard your immune cells, brain, heart, and other organs.
- Improved Energy and Metabolic Health: Supports steady energy levels and metabolic balance. Trehalose offers a smooth source of energy without blood sugar spikes2, while American Ginseng is an adaptogen that fights fatigue and may improve mental clarity. Together they aid in stress adaptation, blood sugar regulation, and even healthy cholesterol levels, contributing to overall wellness and stamina.
- High-Quality, Research-Backed Ingredients: Every ingredient is backed by scientific research and sourced for excellence. From Canadian-grown Reishi and Ginseng (renowned for their rich active compounds) to premium trehalose and grape polyphenols, TrehaShield™ assures quality and efficacy. All components are present in effective dosages used in studies, and the formula is crafted based on emerging nutritional science – such as using trehalose to mimic fasting benefitsior combining immunomodulators for maximal effect.
TrehaShield™ represents a fusion of tradition and innovation: it leverages ancient remedies like Lingzhi and Ginseng, validated by modern clinical evidence, and augments them with novel ingredients like Trehalose and refined Polyphenols. The result is a comprehensive wellness formula that not only bolsters your immune defenses naturally but also supports your body’s key systems (energy, metabolism, antioxidant status) for optimal health year-round. With TrehaShield™, you are investing in a fortified immune system and a more resilient you – backed by science and delivered with quality. Embrace the power of this advanced material and experience the difference of true immune vitality.
[i] Zhang Y, DeBosch BJ. Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms. Curr Opin Clin Nutr Metab Care. 2019;22(4):303-310. doi:10.1097/MCO.0000000000000568
[ii] Yoshizane C, Mizote A, Yamada M, et al. Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects. Nutr J. 2017;16(1):9. Published 2017 Feb 6. doi:10.1186/s12937-017-0233-x
[iii] Martinon D, Borges VF, Gomez AC and Shimada K (2020) Potential Fast COVID-19 Containment With Trehalose. Front. Immunol. 11:1623. doi: 10.3389/fimmu.2020.01623
[iv] Wachtel-Galor S, Yuen J, Buswell JA, et al. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 9. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92757/
[v] Predy GN, Goel V, Lovlin R, Donner A, Stitt L, Basu TK. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ. 2005;173(9):1043-1048. doi:10.1503/cmaj.1041470
[vi] McElhaney JE, Gravenstein S, Cole SK, et al. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc 2004 Jan;52(1) : 13-9.
[vii] Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-93.
[viii] Assinewe VA, et al. Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stmulate TNFalpha production by alveolar macrophages. Phytomedicine 2002;9:398-404.
[ix] Vuksan V, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13.
[x] Chen SE. American ginseng. III. Pharmacokinetics of ginsenosides in the rabbit. Eur J Drug Metab Pharmacokinet 1980;5:161-8.
[xi] Vuksan V, et al. American ginseng (Panax quinquefolius L.) attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individuals. Am J Clin Nutr 2001;73:753-8.
[xii] Barton DL, Liu H, Dakhil SR, et al. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013 Aug 21;105(16):1230-8.
[xiii] Li X, Yang M, Zhang YL, et al. Ginseng and Ginseng Herbal Formulas for Symptomatic Management of Fatigue: A Systematic Review and Meta-Analysis. J Integr Complement Med. 2023 Feb 1. doi: 10.1089/jicm.2022.0532.
[xiv] Bower JE, Lacchetti C, Alici Y, et al. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update. J Clin Oncol. 2024 May 16:JCO2400541.
[xv] Scholey A, Ossoukhova A, Owen L, et al. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology (Berl). 2010 Oct;212(3):345-56.
[xvi] Chen EY, Hui CL. HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled study. Phytother Res. 2012 Aug;26(8):1166-72.
[xvii] Ossoukhova A, Owen L, Savage K, et al. Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults. Hum Psychopharmacol. 2015 Mar;30(2):108-22.
[xviii] Magrone T, Candore G, Caruso C, Jirillo E, Covelli V. Polyphenols from red wine modulate immune responsiveness: biological and clinical significance. Curr Pharm Des. 2008;14(26):2733-2748. doi:10.2174/138161208786264098
[xix] Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem. (2007) 282:5641–52. doi: 10.1074/jbc.M609532200